Sjögren syndrome is a chronic, inflammatory autoimmune disease with significant oral and systemic complications. Oral manifestations and complications of this disease include parched oral mucosa, discomfort, increased risk for caries and dental erosion, increased prevalence of candidal infections, and other conditions. A diagnosis of Sjögren syndrome may be suspected if dry mouth and dry eyes are both present, however a definitive diagnosis requires further investigation. Management of the oral complications of this syndrome requires palliative care/treatment of dry mouth and preventive care. Given the increased risk for oral diseases and non-Hodgkin’s lymphoma, frequent recalls and therapy are required.